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PROF. YUNG,
Ken Kin Lam (¯Î«ØÀM) |
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B.Sc. (Hons.), HKBU; M.Phil., HKU; D.Phil., Oxford
Professor
Department of Biology, Hong Kong Baptist University
Rm T1103; (852) 3411-7060kklyung@hkbu.edu.hk |
Current Research Interests:
- Neurobiology of receptors and neurological diseases
- Neurotoxicology
- Neuropharmacology
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RESEARCH PROJECTS
SELECTED PUBLICATIONS
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E.K.Y. Chung, L.W. Chen, Y.S. Chan and K.K.L. Yung, ¡§Down
regulations of glial glutamate transporters after dopamine denervation in the
striatum of six-hydroxydopamine-lesioned rats¡¨, J. Comp. Neurol. (In
press, 2008).
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Y.C. Tse, C.H., Lai, S.K. Lai, J.X. Liu, K.K.L. Yung, D.K.Y.
Shum and Y.S. Chan, ¡§Developmental expression of NMDA and AMPA receptor
subunits in vestibular nuclear neurons that encode gravity-related horizontal
orientations¡¨, J. Comp. Neurol. 508, 343-64
(2008).
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L.W. Chen, Y.Q Wang., G.L. Bian, L.C Wei and K.K.L.Yung,
¡§Neurokinin-3 peptide instead of neurokinin-1 synergistically exacerbates
kainic acid-inducing degeneration of neurons in the substantia nigra of mice¡¨,
J. Neurochem. 105, 203-216 (2008).
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L. Chen, K.K.L. Yung and W.H. Yung, ¡§Neurotensin selectively
facilitates glutamatergic transmission in globus pallidus¡¨, Neuroscience
141, 1871-1878 (2006).
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S.K. Lai, C.H. Lai, K.K.L. Yung, D.K. Shum and Y.S. Chan,
¡§Maturation of otolith-related brainstem neurons in the detection of vertical
linear acceleration in rats¡¨, Eur. J. Neurosci. 23: 2431-2446 (2006).
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W.K. Lau, W.H. Yung, Y.S. Chan and K.K.L. Yung,
¡§Developmental assembly of GABA receptors in the rat substantia nigra¡¨, Basal
Ganglia VIII, pp. 229-240. Springer, New York (2005).
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L.W. Chen, K.K.L. Yung and Y.S. Chan, ¡§Reactive astrocytes
as potential manipulation targets in novel cell replacement therapy of
Parkinson's disease¡¨, Curr. Drug Targets 6: 821-833 (2005).
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R.W.C. Lam, Y.S. Chan and K.K.L. Yung, ¡§Differential localization of
metabotropic glutamate receptors 1£\ and 2/3 in the rat striatum during early
postnatal development¡¨, Neuroembryology 3: 26-41 (2004-05).
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L. Chen, K. K. L. Yung, and W. H. Yung, ¡§Neurotensin depolarizes globus
pallidus neurons in rats via neurotensin type-1 receptor¡¨, Neuroscience 125:
853-859 (2004).
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L. W. Chen, H. J. Hu, H. L. Liu, K. K. L. Yung, and Y. S. Chan,
¡§Identification of brain-derived neurotrophic factor in nestin-expressing
astroglial cells in the neostriatum of
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice¡¨, Neuroscience 126:
941-953 (2004).
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L. W. Chen, K. K. L. Yung, and Y. S. Chan, ¡§Neurokinin peptides and
neurokinin receptors as potential therapeutic intervention targets of basal
ganglia in the prevention and treatment of Parkinson's disease¡¨, Current Drug
Targets 5: 197-206 (2004) (review).
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H. J. Hu, L. W. Chen, K. K. L. Yung, and Y. S. Chan, ¡§Differential expression
of AMPA receptor subunits in substance P receptor-containing neurons of the
caudate-putamen of rats¡¨, Neurosci. Res. 49: 281-288 (2004).
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C. H. Lai, Y. C. Tse, D. K. Y. Shum, K. K. L. Yung, and Y. S. Chan, ¡§Fos
expression in otolith-related brainstem neurons of postnatal rats following
off-vertical axis rotation¡¨, Journal of Comparative Neurology 470: 282-296
(2004).
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S. K. Lai, T. K. Y. Ng, W. K. Lau, M. S. Yang, C. K. C. Wong, Y. S. Chan, and
K. K. L. Yung, ¡§Selective knockdown of gene expression of N-methyl-D-aspartate
receptor one ameliorates parkinsonian motor symptom in
6-hydroxydopamine-lesioned rats¡¨, Neurochem. Int. 45: 11-22 (2004).
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W. K. Lau, P. W. Lui, C. K. C. Wong, Y. S. Chan, and K. K. L. Yung,
¡§Differential expression of N-methyl-D-aspartate receptor subunit messenger
ribonucleic acids and immunoreactivity in the rat neostriatum during postnatal
development¡¨, Neurochem. Int. 43: 47-65 (2003).
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P. W. Lui, K. C. Suen, Y. S. Chan, W. H. Yung, and K. K. L. Yung, ¡§Striatal
neurons but not nigral dopaminergic neurons in neonatal primary cell culture
express endogenous functional N-methyl-D-aspartate receptors¡¨, Brain Res. Mol.
Brain Res. 120: 9-21 (2003).
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Y. S. Chan, L. W. Chen, C. H. Lai, D. K. Shum, K. K. L. Yung, and F. X.
Zhang, ¡§Receptors of glutamate and neurotrophin in vestibular neuronal
functions¡¨, J. Biomed. Sci. 10: 577-587 (2003) (review).
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W. S. Chan, C. W. Yeung, E. K. Y. Chung, W. K. Lau, Y. S. Chan, and K. K. L.
Yung, ¡§Differential expression of
alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionate glutamate receptors in the
rat striatum during postnatal development¡¨, Neurosignals 12: 302-309 (2003)
(Invited).
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| Prof. Ken, KL Yung |
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