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Dr. MS Yang

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Prof. J Zhang
Prof. Ricky, NS Wong
Prof. MH Wong
Prof. NK Mak
Dr. Yi Ji Xia
Prof. Jonathan WC Wong
Dr. Mildred, SM Yang
Prof. Ken, KL Yung
Dr. KC Cheung
Dr. Y Jiang
Dr. JW Qiu
Dr. Chris, KC Wong
Dr. Y Liang
Dr. SS Chung

RESEARCH TOPICS

DR. YANG, Mildred Sze Ming (·¨´µ±Ó)

B.A., UCSD; M.A., Columbia; Ph.D., Washington Univ.

Associate Professor

Department of Biology, Hong Kong Baptist University

Rm. T1019; (852) 3411-7058

msyang@hkbu.edu.hk

Current Research Interests: 
  • In vitro and In vivo toxicological assessment of chemicals
  • Mechanism of cell injury
  • Protection against neuronal and hepatic cell injury
  • Cellular metabolism
  • Herbal medicine for treatment of avian flu

RESEARCH TOPICS

  • Study of drug-herb interaction between Oseltamivir (Tamiflu) and herbal medicine for treatment of Avian Flu.
  • Ginsenosides as functional ligands of steroid hormone receptors: from ligand-receptor interactions to cellular homeostasis.
  • Application of a comprehensive set of biomarkers for evaluating risk for various tissues upon exposure to persistent toxic substances.

SELECTED PUBLICATIONS

  1. Lin, T., Mak, N.K. and Yang, M.S. (2008). MAPK regulate p53-dependent cell death induced by Benzo[a]pyrene: involvement of p53 phosphorylation and acetylation. Toxicology 247, 145-153 (2008).

  2. Yang, M.S., Li, D, Lin, T., Zheng, J.J., Zheng, W. and Qu, J.Y. (2008).  Increase in intracellular free/bound NAD[P]H as a cause of Cd induced oxidative stress in the HepG2 cells. Toxicology, 247, 6-10 (2008).

  3. Yang, M.S., Lin, T., D. Li and Qu, J.Y.(2008).  Analysis of intracellular NADH level in the HepG2 cells and its relation with cellular energy level and cell death following acute cadmium exposure. In: Metal Ions in Biology and Medicine. Collery P, Theophanides T, Maymard I, Collery T. (Eds.) Vol. 10, John Libbey Eurotext, Paris (2008).

  4. Lin T. and Yang, M.S. (2008).  Benzo[a]pyrene induced necrosis in the HepG2 cells via PARP-1 activation and NAD+ depletion. Toxicology 245, 147-153.

  5. Lau, M.C., Chan, K.M., Leung, K.M.Y., Luan, T.G., Yang, M.S. and Qiu, J.W. (2007).  Acute and chronic toxicity of tributyltin to various life stages of the marine polychaete Hydroides elegans. Chemosphere 69, 135-144.

  6. Yang, M.S., Yu, L.C. and Pat S. W. (2007).  Manipulation of energy and redox state in the C6 glioma cells by buthionine sulfoxamine and N-acetylcysteine and the effect on cell survival to Cd toxicity. Cellular and Mol. Biology 53, 56-61.

  7. Lin, T. and Yang, M.S. (2007).  Benzo[a]pyrene-induced elevation of GSH level protects against oxidative stress and enhances xenobiotic detoxification in human HepG2 cells. Toxicology 235, 1-10.

  8. Yang, M.S., Chan, H.W., and Yu, L.C. (2006). Glutathione peroxidase and glutathione reductase activities are partially responsible for determining the susceptibility of cells to oxidative stress. Toxicology 226, 126-130.

  9. Yang, M.S., Tse, W.K.F.,  Yu, L.C.,  Li, K.M.,  Mak, N.K. and R. C. Gupta (2005). Energy and redox states in the C6 glioma cells following acute exposure to Zn, Se+4 and Se+6 and the correlation with apoptosis. Toxicol. Mech. Methods 16, 13-19.

  10. Yang, M.S., Yu, L.C. and Gupta, R.C. (2005). Analysis of multiple metabolomics subsets in vitro: Methodological considerations. Toxicol. Mech. Methods 15, 29-32.

  11. Cai Zongwei, Qian Tianxiu, and Yang, M.S. (2004). Ion-pairing liquid chromatography coupled with mass spectrometry for the simultaneous determination of nucleosides and nucleotides. Chinese J. Chromatography  22, 358-360.

  12. Yang, M.S., Yu, L.C. and Gupta, R.C. (2004). Analysis of changes in energy and redox states in HepG2 hepatoma and C6 glioma cells upon exposure to Cd. Toxicology 201, 105-113.

  13. Lai, S.K., Ng, T.K.Y., Lau, W.K., Yang, M.S., Wong, C.K.C., Chan, Y.S. and Yung, K.K.L. (2004). Selective knockdown of gene expression of N-methyl-D-aspartate receptor one ameliorates parkinsonian motor symptom in 6-hydroxydopamine-lesioned rats. Neurochem. Int. 45, 11-22.

  14. Tianxiu Qian, Yang, M.S. and Cai Zhongwai (2003) Determination of adenosine nucleotides in cultured cells by ion-pairing liquid chromatography. Analytical Biochem. 325, 77-84.

  15. Yang, M.S. and Gupta, R.C. (2003). Modulation of energy metabolism in C6 glioma cells as a possible mechanism contributing to Zn neurotoxicity. Toxicol. Mech. Methods 13, 269-275.

  16. Yang, M.S. and Ramesh C. Gupta (2003). Determination of energy charge potential in the C6 glioma and the HepG-2 cell culture. Toxicol. Mech. Methods 13, 97-101.

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Dr. Mildred, SM Yang

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