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| DR. YANG,
Mildred Sze Ming (·¨´µ±Ó) |
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B.A., UCSD; M.A., Columbia; Ph.D., Washington Univ.
Associate Professor
Department of Biology, Hong Kong Baptist University
Rm. T1019; (852) 3411-7058
msyang@hkbu.edu.hk |
Current Research Interests:
- In vitro and In vivo toxicological assessment of chemicals
- Mechanism of cell injury
- Protection against neuronal and hepatic cell injury
- Cellular metabolism
- Herbal medicine for treatment of avian flu
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RESEARCH TOPICS
RESEARCH
TOPICS
- Study of drug-herb interaction between Oseltamivir (Tamiflu) and herbal medicine for
treatment of Avian Flu.
- Ginsenosides as functional ligands of steroid hormone receptors: from ligand-receptor
interactions to cellular homeostasis.
- Application of a comprehensive set of biomarkers for evaluating risk for various tissues upon exposure to persistent
toxic substances.
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SELECTED PUBLICATIONS
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Lin, T., Mak, N.K. and Yang, M.S. (2008). MAPK
regulate p53-dependent cell death induced by Benzo[a]pyrene: involvement of
p53 phosphorylation and acetylation. Toxicology 247, 145-153 (2008).
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Yang, M.S., Li, D, Lin, T., Zheng,
J.J., Zheng, W. and Qu, J.Y. (2008). Increase in intracellular
free/bound NAD[P]H as a cause of Cd induced oxidative stress in the HepG2
cells. Toxicology, 247, 6-10 (2008).
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Yang, M.S., Lin, T., D. Li and Qu,
J.Y.(2008). Analysis of intracellular NADH level in the HepG2 cells and
its relation with cellular energy level and cell death following acute cadmium
exposure. In: Metal Ions in Biology and Medicine. Collery P, Theophanides T,
Maymard I, Collery T. (Eds.) Vol. 10, John Libbey Eurotext, Paris (2008).
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Lin T. and Yang, M.S.
(2008). Benzo[a]pyrene
induced necrosis in the HepG2 cells via PARP-1 activation and NAD+ depletion.
Toxicology 245, 147-153.
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Lau, M.C., Chan, K.M., Leung, K.M.Y.,
Luan, T.G., Yang, M.S. and Qiu, J.W. (2007).
Acute and chronic toxicity of tributyltin to various life stages of the marine polychaete Hydroides elegans.
Chemosphere 69, 135-144.
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Yang, M.S., Yu, L.C. and Pat S. W. (2007).
Manipulation of energy and redox state in the C6 glioma cells by buthionine
sulfoxamine and N-acetylcysteine and the effect on cell survival to Cd
toxicity. Cellular and Mol. Biology 53,
56-61.
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Lin, T. and Yang, M.S. (2007).
Benzo[a]pyrene-induced elevation of GSH level protects against oxidative
stress and enhances xenobiotic detoxification in human HepG2 cells.
Toxicology 235, 1-10.
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Yang, M.S., Chan, H.W., and Yu, L.C.
(2006). Glutathione peroxidase and glutathione reductase activities are
partially responsible for determining the susceptibility of cells to oxidative
stress. Toxicology 226, 126-130.
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Yang, M.S., Tse,
W.K.F.,
Yu, L.C.,
Li, K.M., Mak, N.K. and R. C. Gupta (2005). Energy and redox states in the C6 glioma
cells following acute exposure to Zn, Se+4 and Se+6 and
the correlation with apoptosis. Toxicol. Mech. Methods 16, 13-19.
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Yang, M.S., Yu, L.C. and Gupta, R.C.
(2005). Analysis of multiple metabolomics subsets in vitro: Methodological
considerations. Toxicol. Mech. Methods 15, 29-32.
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Cai Zongwei, Qian Tianxiu, and Yang,
M.S. (2004). Ion-pairing liquid chromatography coupled with mass
spectrometry for the simultaneous determination of nucleosides and
nucleotides. Chinese J. Chromatography 22, 358-360.
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Yang, M.S.,
Yu, L.C. and Gupta, R.C.
(2004). Analysis of changes in energy and redox states in HepG2 hepatoma and
C6 glioma cells upon exposure to Cd. Toxicology 201, 105-113.
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Lai, S.K., Ng, T.K.Y., Lau, W.K., Yang,
M.S., Wong, C.K.C., Chan, Y.S. and Yung, K.K.L. (2004). Selective knockdown of
gene expression of N-methyl-D-aspartate receptor one ameliorates parkinsonian
motor symptom in 6-hydroxydopamine-lesioned rats. Neurochem. Int. 45,
11-22.
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Tianxiu Qian, Yang, M.S. and Cai Zhongwai
(2003) Determination of adenosine nucleotides in cultured cells by ion-pairing
liquid chromatography. Analytical Biochem. 325, 77-84.
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Yang, M.S. and Gupta, R.C. (2003).
Modulation of energy metabolism in C6 glioma cells as a possible mechanism
contributing to Zn neurotoxicity. Toxicol. Mech. Methods 13, 269-275.
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Yang, M.S. and Ramesh C. Gupta (2003).
Determination of energy charge potential in the C6 glioma and the HepG-2 cell
culture. Toxicol. Mech. Methods 13, 97-101.
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| Dr. Mildred, SM Yang |
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