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Prof. NK Mak

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Prof. Chris, KC Wong
Prof. Ricky, NS Wong
Prof. MH Wong
Prof. NK Mak
Prof. Jonathan WC Wong
Prof. Ken, KL Yung
Dr. Yi Ji Xia
Dr. JW Qiu
Dr. SS Chung
Dr. Y Liang
Dr. ZY Zhao
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Dr. HM Zhang
Dr. B Yan
Dr. Patrick, YK Yue
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Prof. J Zhang
PROF. MAK, Nai Ki (³Á¤D§Á)

B.Sc. (Hons.), CUHK; Ph.D., Australian National University

Professor

Department of Biology, Hong Kong Baptist University

Rm. T1117; (852) 3411-7059

nkmak@hkbu.edu.hk

Current Research Interests: 
  • Development of photosensitizers for cancer therapy
  • Development of anti-tumor and antiviral compounds from natural products

RESEARCH PROJECTS

SELECTED PUBLICATIONS

  1. Y.M. Lee, C.M. Ting, Y.K. Cheng, T.P. Fan, R.N. Wong, M.L. Lung and N.K. Mak, ¡§Mechanisms of 2-methoxyestradiol-induced apoptosis and G2/M cell-cycle arrest of nasopharyngeal carcinoma cells,¡¨ Cancer Lett. (In press).

  2. F.L. Jiang, C.T. Poon, W.K. Wong, H.K. Koon, N.K. Mak, C.Y. Choi, D.W. Kwong and Y. Liu, ¡§An amphiphilic bisporphyrin and its Yb(III) complex: development of a bifunctional photodynamic therapeutic and near-infrared tumor-imaging agent¡¨, Chembiochem. 9 (issue 7), 1034 ¡V 1039 (2008).

  3. T. Lin, N.K. Mak and M.S. Yang, ¡§MAPK regulate p53-dependent cell death induced by benzo[a]pyrene: involvement of p53 phosphorylation and acetylation¡¨, Toxicology. 247 (issue 2-3), 145 ¡V 153 (2008).

  4. M. Naidu, C.Y. Kuan, W.L. Lo, M. Raza., A. Tolkovsky, N.K. Mak, R.N.Wong and R. Keynes, ¡§Analysis of the action of euxanthone, a plant-derived compound that stimulates neurite outgrowth¡¨, Neuroscience, 148 (issue 4), 915 ¡V 924. (2007).

  5. K.N. Leung, N.K. Mak, and M.C. Fung, ¡§Cytokines in the Differentiation Therapy of Leukemia: From Laboratory Investigations to Clinical Applications¡¨, Critical Reviews in Clinical Laboratory Sciences 42: 1-42 (2005).

  6. X.Y. Wei, C.Y. Leung, C.K.C. Wong, X.L. Shen, R.N.S. Wong, Z.W. Cai and N.K. Mak, ¡§A new TCDD Antagonist from the Chinese Medicinal Herb Isatis indigotica¡¨, Journal of Natural Products 68: 427-429 (2005).

  7. O.L. Lui, N.K. Mak, and K.N. Leung, ¡§Conjugated linoleic acid induces monocytic differentiation of murine myeloid leukemia cells¡¨, International Journal of Oncology 27(6), 1737 ¡V 1743 (2005).

  8. N.K. Mak, K.M. Li, W.N. Leung, R.N.S. Wong, D. P. Huang, M. L. Lung, Y. K. Lau, and C.K. Chang, ¡§Involvement of both endoplasmic reticulum and mitochondria in photokilling of nasopharyngeal carcinoma cells by the photosensitizer Zn-BC-AM¡¨, Biochemical Pharmacology 68, 2387 ¡V 2396 (2004).

  9. N.K. Mak, C.Y. Leung, X.Y. Wei, X.L. Shen, R.N.S. Wong, K.N. Leung, and M.C. Fung, ¡§Inhibition of RANTES expression by indirubin in influenza virus infected human bronchial epithelial cells¡¨, Biochemical Pharmacology 67: 167-17 (2004).

  10. M.C. Fung, S.F. Sia, K.N. Leung, and N.K. Mak, ¡§Detection of differentiation expression of mouse interferon-alpha subtypes by polymerase chain reaction using specific primers¡¨, Journal of Immunological Methods 284: 177-186 (2004).

  11. H.L. Lung, W.K. Ip, Z.Y. Chen, N.K. Mak and K.N. Leung, ¡§Comparative study of the growth-inhibitory and apoptosis-inducing activities of black tea theaflavins and green tea catechin on murine myeloid leukemia cells¡¨, Internal Journal of Molecular Medicine, 13(3): 465-471 (2004).

  12. N.K. Mak, T.W. Kok, R.N.S. Wong, S.W. Lam, Y.K. Lau, W.N. Leung, N.H. Cheung, D.P Huang, L.L. Yeung and C.K. Chang, ¡§Photodynamic Activities of Sulfonamide Derivatives of Porphycene on Nasopharyngeal Carcinoma Cells¡¨, Journal of Biomedical Sciences 10(4): 418-429 (2003).

Prof. NK Mak

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