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PROF. MAK, Nai
Ki (³Á¤D§Á) |
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B.Sc. (Hons.), CUHK; Ph.D., Australian National
University
Professor
Department of Biology, Hong Kong Baptist University
Rm. T1117; (852) 3411-7059
nkmak@hkbu.edu.hk |
Current Research Interests:
- Development of photosensitizers for cancer therapy
- Development of anti-tumor and antiviral compounds
from natural products
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RESEARCH PROJECTS
SELECTED PUBLICATIONS
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Y.M. Lee, C.M. Ting, Y.K. Cheng, T.P. Fan, R.N. Wong, M.L.
Lung and N.K. Mak, ¡§Mechanisms of 2-methoxyestradiol-induced apoptosis and G2/M
cell-cycle arrest of nasopharyngeal carcinoma cells,¡¨ Cancer Lett. (In
press).
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F.L. Jiang, C.T. Poon, W.K. Wong, H.K. Koon, N.K. Mak, C.Y.
Choi, D.W. Kwong and Y. Liu, ¡§An amphiphilic bisporphyrin and its Yb(III)
complex: development of a bifunctional photodynamic therapeutic and
near-infrared tumor-imaging agent¡¨, Chembiochem. 9 (issue 7), 1034 ¡V 1039
(2008).
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T. Lin, N.K. Mak and M.S. Yang, ¡§MAPK regulate p53-dependent
cell death induced by benzo[a]pyrene: involvement of p53 phosphorylation and
acetylation¡¨, Toxicology. 247 (issue 2-3), 145 ¡V 153 (2008).
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M. Naidu, C.Y. Kuan, W.L. Lo, M. Raza., A. Tolkovsky, N.K.
Mak, R.N.Wong and R. Keynes, ¡§Analysis of the action of euxanthone, a
plant-derived compound that stimulates neurite outgrowth¡¨, Neuroscience,
148 (issue 4), 915 ¡V 924. (2007).
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K.N. Leung, N.K. Mak, and M.C. Fung, ¡§Cytokines in the
Differentiation Therapy of Leukemia: From Laboratory Investigations to Clinical
Applications¡¨, Critical Reviews in Clinical Laboratory Sciences 42: 1-42
(2005).
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X.Y. Wei, C.Y. Leung, C.K.C. Wong, X.L. Shen, R.N.S. Wong, Z.W.
Cai and N.K. Mak, ¡§A new TCDD Antagonist from the Chinese Medicinal Herb Isatis
indigotica¡¨, Journal of Natural Products 68: 427-429 (2005).
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O.L. Lui, N.K. Mak, and K.N. Leung, ¡§Conjugated linoleic acid
induces monocytic differentiation of murine myeloid leukemia cells¡¨,
International Journal of Oncology 27(6), 1737 ¡V 1743 (2005).
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N.K. Mak, K.M. Li, W.N. Leung, R.N.S. Wong, D. P. Huang, M. L.
Lung, Y. K. Lau, and C.K. Chang, ¡§Involvement of both endoplasmic reticulum and
mitochondria in photokilling of nasopharyngeal carcinoma cells by the
photosensitizer Zn-BC-AM¡¨, Biochemical Pharmacology 68, 2387 ¡V 2396
(2004).
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N.K. Mak, C.Y. Leung, X.Y. Wei, X.L. Shen, R.N.S. Wong, K.N.
Leung, and M.C. Fung, ¡§Inhibition of RANTES expression by indirubin in influenza
virus infected human bronchial epithelial cells¡¨, Biochemical Pharmacology
67: 167-17 (2004).
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M.C. Fung, S.F.
Sia, K.N. Leung, and N.K. Mak, ¡§Detection of differentiation
expression of mouse interferon-alpha subtypes by polymerase chain reaction using
specific primers¡¨, Journal of Immunological Methods 284: 177-186 (2004).
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H.L. Lung, W.K. Ip, Z.Y. Chen, N.K. Mak and K.N. Leung, ¡§Comparative study of
the growth-inhibitory and apoptosis-inducing activities of black tea theaflavins
and green tea catechin on murine myeloid leukemia cells¡¨, Internal Journal of
Molecular Medicine, 13(3): 465-471 (2004).
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N.K. Mak, T.W. Kok, R.N.S. Wong, S.W. Lam, Y.K. Lau, W.N.
Leung, N.H. Cheung, D.P Huang, L.L. Yeung and C.K. Chang, ¡§Photodynamic
Activities of Sulfonamide Derivatives of Porphycene on Nasopharyngeal Carcinoma
Cells¡¨, Journal of Biomedical Sciences 10(4): 418-429 (2003).
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| Prof. NK Mak |
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