卞兆祥博士
臨床部主任及副教授
中醫藥、中藥藥理、內臟痛及新藥研製專家
bzxiang@hkbu.edu.hk
卞博士1988年畢業於南京中醫藥大學獲中醫學學士學位,1991年獲北京中醫藥大學碩士學位,1994年於廣州中醫藥大學獲醫學博士學位。畢業後於廣州中醫藥大學從事科研、臨床及教學工作。曾獲得國家科技進步二等獎等多項科研獎勵。
2001年加入香港浸會大學中醫藥學院後,先後承擔包括來自香港賽馬會中藥研究院基金項目在內的多項研究工作。卞博士長期從事中醫藥治療消化系疾病的基礎與臨床研究。基礎研究重點在於從組織病理、細胞及分子水平探討內藏痛的病理機制及中藥單體及復方對內髒痛的作用及其可能的機制。臨床研究方面重點在於探討中藥復方治療功能性胃腸道疾病、潰瘍性結腸炎、克隆氏病等的療效與安全性,以及中草藥臨床研究規范化問題。
卞博士領導的研究組正公開招收博士後研究生人員,研究方向:內藏痛的病理機制和/或中藥的治療作用。
部份著作及論文
Li Z, Zhang XJ, Xu HX, Sung JJY, Bian ZX*. Intracolonical administration of protease-activated receptor-2 agonists produced visceral hyperalgesia by up-regulating serotonin in the colon of rats. Eur J Pharmacol. 2009; 606(1-3):199-204.
Bian ZX*, Li Z, Zhang XJ, Xu HX, Sung JJY. Unbalanced expression of protease-activated receptors-1 and -2 in the colon of diarrhea-predominant irritable bowel syndrome patients. J Gastroenterol. 2009; 44(7):666-674.
Chung EK, Zhang XJ, Xu HX, Sung JJY, Bian ZX*. Neonatal Maternal Separation Increases Brain-Derived Neurotrophic Factor and Tyrosine Kinase Receptor B Expression in the Descending Pain Modulatory System. Neurosignals. 2009; 17:213-221.
Qi SD, Tian SL, Xu HX, Sung JJ, Bian ZX*. Quantification of luminally released serotonin in rat proximal colon by capillary electrophoresis with laser-induced fluorescence detection. Anal Bioanal Chem. 2009; 393(8):2059-66.
Zhang XJ, Li Z, Chung EKY, Zhang HQ, Xu HX, Sung JJY, Bian ZX*. Activation of Extracellular signal-regulated protein kinase is associated with colorectal distension-induced spinal and supraspinal neuronal response and neonatal maternal separation-induced visceral hyperalgesia in rats. J Mol Neurosci. 2009;37(3):274-287.
Cheng CW, Bian ZX*. How can apples be mixed with oranges? Explore (NY). 2008;4(6):379.
Bian ZX*, Moher D, Li YP, Wu TX, Dagenais S, Cheng CW, Li J, Li TQ. Appropriately selecting and concisely reporting the outcome measures of randomized controlled trials of traditional Chinese medicine (CONSORT for TCM). Journal of Chinese integrative medicine. 2008;6:771-5.
Cheng CW, Bian ZX*, Li YP, Moher D, Wu TX, Dagenais S, Li J, Li TQ. Transparently reporting adverse effects of Traditional Chinese Medicine interventions in randomized controlled trials. Journal of Chinese integrative medicine. 2008;6:881-6.
Bian ZX*, Moher D, Li YP, Wu TX, Dagenais S, Cheng CW, Li J, Li TQ. Precise reporting of traditional Chinese medicine interventions in randomized controlled trials. Journal of Chinese integrative medicine. 2008; 6: 661-667.
Chan KF, Ng YN, Bian ZX, Shi Y, Lee SP, Ng KY. Social work at the Chinese Medicine system in Hong Kong: opportunities and challenges. Soc Work Health Care. 2008;46:39-55.
Zhang XJ, Li Z, Leung WM, Liu L, Xu HX, Bian ZX*. The analgesic effect of paeoniflorin on neonatal maternal separation-induced visceral hyperalgesia in rats. J Pain. 2008; 9:497-505.
Bian ZX*, Moher D. Clinical Studies and randomized controlled trials in Chinese herbal medicine: A historical and contemporary review. Thieme Almanac 2008; 5-17.
Chung EK, Zhang XJ, Xu HX, Sung JJ, Bian ZX*. Visceral hyperalgesia induced by neonatal maternal separation is associated with nerve growth factor-mediated central neuronal plasticity in rat spinal cord. Neuroscience. 2007;149:685-95.
Chung EK, Zhang XJ, Li Z, Zhang HQ, Xu HX, Bian ZX*. Neonatal maternal separation enhances central sensitivity to noxious colorectal distention in rat. Brain Res. 2007; 1153:68-77.
Wu TX, Li YP, Bian ZX, Li TQ, Li J, Dagenais S, Moher D for the CONSORT for TCM group. Consolidated standards for reporting trials of traditional Chinese medicine (CONSORT for TCM), Chinese Journal of Evidence-based Medicine. 2007; 7:625-630.
Xie Y, Jiang ZH, Zhou H, Cai X, Wong YF, Liu ZQ, Bian ZX, Xu HX, Liu L. Combinative method using HPLC quantitative and qualitative analyses for quality consistency assessment of an herbal medicinal preparation. J Pharm Biomed Anal. 2007; 43(1):204-12.
Cai X, Zhou H, Wong YF, Xie Y, Liu ZQ, Jiang ZH, Bian ZX, Xu HX, Liu L. Suppression of the onset and progression of collagen-induced arthritis in rats by QFGJS, a preparation from an anti-arthritic Chinese herbal formula. J Ethnopharmacol. 2007;110(1):39-48.
Dagenais S, Tricco AC, Bian ZX, Huang WH, Moher D. Critical appraisal of clinical studies in Chinese herbal medicine. Journal of Chinese integrative medicine. 2006; 4:455-66.
Bian ZX*, WU TX, Liu L, Miao JX, Wong HF, Song L, Sung JJY. Effectiveness of the Chinese herbal formula TongXieYaoFang for irritable bowel syndrome: a systematic review. J Altern Complement Med. 2006; 12:401-407.
Tian XY, Bian ZX*, Hu XG, Zhang XJ, Liu L, Zhang HQ. Electro-acupuncture attenuates stress-induced defecation in rats with chronic visceral hypersensitivity via serotonergic pathway. Brain Res. 2006;1088:101-8.
Bian ZX*. Stratification by sex and subgroup is necessary for RCT on IBS. Gut. 2006;55:743-4.
Bian ZX*, Zhang GS, Wong KL, Hu XG, Liu L, Yang ZJ, Li M. Inhibitory effects of magnolol on distal colon of guinea pig in vitro. Biol Pharm Bull. 2006;29:790-5.
Bian ZX*, Moher D, Dagenais S, Li YP, Wu TX, Liu L, Miao JX, Song L, Zhang HM. Improving the quality of randomized controlled trials in Chinese herbal medicine, part IV: applying a revised CONSORT checklist to measure reporting quality. Journal of Chinese integrative medicine. 2006;4:233-42.
Leung KS, Bian ZX*, Moher D, Dagenais S, Li YP, Liu L, Wu TX, Miao JX. Improving the quality of randomized controlled trials in Chinese herbal medicine, part III: quality control of Chinese herbal medicine used in randomized controlled trials. Journal of Chinese integrative medicine. 2006; 4:225-32.
Bian ZX*, Moher D, Dagenais S, Li YP, Liu L, Wu TX, Miao JX. Improving the quality of randomized controlled trials in Chinese herbal medicine, part II: control group design. Journal of Chinese integrative medicine. 2006; 4:130-6.
Bian ZX*, Li YP, Moher D, Dagenais S, Liu L, Wu TX, Miao JX, Kwan AK, Song L. Improving the quality of randomized controlled trials in Chinese herbal medicine, part I: clinical trial design and methodology. Journal of Chinese integrative medicine. 2006; 4: 120-9.
Zhou H, Wong YF, Cai X, Liu ZQ, Jiang ZH, Bian ZX, Xu HX, Liu L. Suppressive effects of JCICM-6, the extract of an anti-arthritic herbal formula, on the experimental inflammatory and non-receptive models in rodents. Biol Pharm Bull. 2006; 29: 253-60.
Chung V, Liu L, Bian ZX, Zhao ZZ., Fong WL, Kum WF, Gao J, Li M. The efficacy and safety of herbal medicines for idiopathic parkinson's disease: a systematic review. Movement Disord. 2006; 21:1709-15.
Cai X, Wong YF, Zhou H, Liu ZQ, Xie Y, Jiang ZH, Bian ZX, Xu HX, Liu L. Manipulation of the induction of adjuvant arthritis in SD rats. Inflamm Res 2006;55:368-377.
Cai X, Wong YF, Zhou H, Xie Y, Liu ZQ, Jiang ZH, Bian ZX, Xu HX, Liu L. The comparative study of Sprague-Dawley and Lewis rats in adjuvant-induced arthritis. Naunyn Schmiedebergs Arch. Pharmacol. 2006; 373: 140-147.
Cai X, Zhou H, Wong YF, Xie Y, Liu ZQ, Jiang ZH, Bian ZX, Xu HX, Liu L. Suppressive effects of QFGJS, a preparation from an anti-arthritic herbal formula, on rat experimental adjuvant-induced arthritis. Biochem Biophys Res Commun. 2005; 337: 586-94.
鄭頌華,卞兆祥,李幼平,David Moher,吳泰相,Simon Dagenais,李靜,李廷謙。 中醫藥臨床研究報告中應清晰闡述試驗設計理念,中國循證醫學雜誌 2008,8(3):152-154
吳泰相,李幼平,商洪才,劉關鍵,李靜,陳可冀,張伯禮,楊克虎,徐佩茹,肖鳳,黃玉珊,李浪,李蘭娟,胡世蓮,徐維平,倪衡建,周丹,李潔,卞兆祥,梁繁榮。 提高我國衛生研究能力的策略,中國循證醫學雜誌 2008,8(8):625-628
吳泰相,李幼平,卞兆祥,李廷謙,李靜,Simon Dagenais,David Moher 代表 CONSORT for TCM 工作組。 中醫藥臨床隨機對照試驗報告規範(徵求意見稿),中國循證醫學雜誌 2007,7(8):601-605
卞兆祥。 中醫藥臨床研究療效評價中存在的問題與對策,世界科學技術-中醫藥現代化 2007,9(4):91-95
吳泰相,李幼平,卞兆祥,陳可冀,張伯禮,商洪才,David Moher。 實施臨床試驗報告規範,提高臨床試驗透明度,中國循證醫學雜誌 2007,7(8):551-554
李幼平,吳泰相,劉關鍵,李靜,李廷謙,商洪才,張伯禮,卞兆祥,David Moher。中國循證醫學中心促進中醫藥現代化的策略,中國循證醫學雜誌 2007,7(3):159-161
卞兆祥,劉良,李敏。 SARS後綜合征的辨治,中醫雜誌 2004,45(3):236
張根水,魏毅,卞兆祥。 兩種內臟痛覺超敏大鼠模型的比較研究,醫學理論與實踐 2004,17(7):745-747
卞兆祥。 從SARS疫潮反思中醫藥在香港公共醫療保健體系中應有的角色,青年研究學報 2004,7(1):1-7
卞兆祥,楊顯榮。 規範的臨床研究是中醫藥融入主流醫學的關鍵,中國中西醫結合雜誌 2004,24(4):359-361
卞兆祥。 中醫對抗SARS的定位反思,現代中醫藥 2003,11:10-13
王洪琦,卞兆祥,韓宇霞,劉淑賢,楊慧青,王宏。 中醫類專業課程優化整合的研究與實踐,中國中醫藥現代遠程教育 2003,(3):29-31
劉良,卞兆祥。 中醫藥與老年醫療保健,中醫雜誌 2002,43(7):555-556
卞兆祥,勞紹賢,黃志新,杜標炎,王繼德。 貓胃螺桿菌對二級Balb/C小鼠的實驗性感染,中國中西醫結合脾胃雜誌 2000,8(2):65-66
王建華,卞兆祥。 脾氣虛證本質研究的途徑與方向,中國中醫藥信息雜誌 2000,7(4):7-9
卞兆祥,勞紹賢,周福生,黃志新,杜標炎,崔琪珍,羅琦,歐陽宏,馮春霞。 清熱理氣方治療HP陽性胃炎脾胃鬱熱證的臨床研究,中國中醫藥科技 2000,7(6):356-357
卞兆祥,勞紹賢,王繼德,黃志新,杜標炎,杜群,蘇俊芳。 清熱理氣方對螺桿菌感染性胃炎的作用,廣州中醫藥大學學報 2000,17(1):60-63
梁沛華,卞兆祥,黃志新,劉靜。 寧胃煎治療消化性潰瘍50例療效觀察,新中醫 1999,31(6):20-21
勞紹賢,許鑫梅,周福生,余紹源,賈建國,鄭裕璇,黃志新,郭遂成,卞兆祥。 胃炎消治療胃癌癌前期病變療效分析,中藥新藥與臨床藥理 1997,8(2):72-75
勞紹賢,卞兆祥。 中醫藥治療胃癌癌前病變的臨床研究述評,中醫雜誌 1996,37(11):690-691
卞兆祥,黃志新。 勞紹賢教授辨治胃脘痛經驗,新中醫 1996,7:10-12
卞兆祥,勞紹賢,黃志新。 幽門螺旋菌的現代醫學和中醫學研究進展,深圳中西醫結合雜誌 1995,(4):35-37
卞兆祥,王建華,勞紹賢,許鑫梅。 從調理脾胃方藥臨床藥效研究探討中藥臨床藥理研究的思路和方法,中藥藥理與臨床 1994,(6):45-48
卞兆祥,王建華,勞紹賢,許鑫梅。 消化性潰瘍病證關系探討 中國中西醫結合消化雜誌 1994,2(3):1-4
卞兆祥,王建華,勞紹賢,許鑫梅。 脾氣虛證、肝胃不和證、肝鬱脾虛證定量診斷方法,廣州中醫藥大學學報 1994,11(3):126-129
卞兆祥,張作記。 肺與膀胱相通初探,遼寧中醫雜誌 1991,(1):7-8
連增林,卞兆祥。 略述仲景察小便診病法,河南中醫 1991,11(2):10-11
卞兆祥,蘇寶剛。 異病同治辨-兼論辨證必須與辨病相結合,陝西中醫 1991,12(6):262-263
卞兆祥。 《金匱要略》通腑法探析,四川中醫 1991,(4):2-3
* corresponding author
其他著作及論文